Dihydrotestosterone - The Key Factor in Male Hair Reduction

Dihydrotestosterone (DHT) is a potent and highly active androgen implicated for men pattern hair loss. Dihydrotestosterone is produced mainly in the prostate gland, testes, adrenal glands and tresses follicles. The formation of dihydrotestosterone involved testosterone as a prohormone. Testosterone is metabolized by either of the two types of isoenzymes: 5-alpha reductase type I actually and 5-alpha reductase type II changing it to a more active dihydro- form.


Androgen target tissues are the sites of dihydrotestosterone formation which include the androgen dependent and androgen sensitive regions in the body. In the androgen sensitive region, the nuclear membrane and microsomes take part in the conversion process. Although, testosterone is produced mainly in the examen, masteron production of dihydrotestosterone occurs anywhere in the body where testosterone has entered the cells of the androgen dependent tissue. In the remaining hair, the androgen dependent areas include the frontotemporal region, the crown and the vertex. Essentially, these are the sites where hair tumble occurs at the beginning of male pattern tresses loss.

Dihydrotestosterone and Male Pattern Hair Loss

Within the androgen dependent areas on the scalp, testo-sterone is transformed into dihydrotestosterone. Dihydrotestosterone then binds to the androgen receptors in the hair follicles. The vom männlichen geschlechtshormon receptors actually bind both testosterone and dihydrotestosterone. However, the dihydro- form has higher affinity to and dissociates more slowly from the receptors. Thus, higher levels of the body hormone are retained in the receptors. The existence of the androgens in the hair follicles actually allows for hair growth. However, in genetically predisposed individuals, high levels of DHT can prevent hair growth, even completely stopping it. As a result, the influenced area on the head little by little thins and may turn completely bald. Even if baldness has not yet occurred, the influenced may still look balding because of progressive miniaturization of hair. Normally, this type of hair loss commences during puberty where the body produces high levels of testosterone.

Dihydrotestosterone can only exert their negative effects on susceptible individuals. Male pattern tresses loss is heritable. Individuals who inherit the gene that predisposes the condition become susceptible to the action of DHT. They are likely to experience hair losing during puberty nevertheless they may well not really notice it until after thirty where considerable amount of hair was lost. The situation influences more than 50 percent of men, but the same condition is also recognized in women.

At present, you pattern hair loss has no cure. Affected individuals, however, can find treatments that can stop hair damage effectively. Since the role of DHT has been recognized and widely accepted, the suggested treatment for the condition is the one which addresses the challenge with DHT. The DHT levels on the scalp should be maintained at levels where it cannot cause harm to the hair follicles. This can be created by instituting treatments that block the production of the hormone such as treatments that prevent the enzyme that catalyzes the conversion process. The particular drugs minoxidil and finasteride are known as DHT blockers because they work mainly by blocking the conversion process. Both drugs are proven effective in stopping male pattern curly hair loss. They could also opt for natural treatments that blocks DHT and encourages hair regrowth.